Tfh cells mediate differentiation of GC B cells into memory and plasma cells via the provision of CD40L and IL-21. Tfh cells can be distinguished from other CD4 ...

T-follicular helper (Tfh) cells are a new subset of effector CD4+ T cells that are specialized in helping B cells in the germinal center reaction.

Jun 17, 2023 · It has been proposed that Tfh cell differentiation is a multi-stage process involving PD-1+CXCR5+ pre-Tfh and PD-1hiCXCR5hi GC-Tfh cell steps, ...

Feb 27, 2024 · 21,22 We propose a concept of TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti- ...

Oct 10, 2017 · Local memory Tfh cells express high-affinity TCRs and localize preferentially in B follicles in the proximity of local memory B cells. Notably, ...

Apr 26, 2021 · The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the ...

Sep 26, 2021 · CD4+ T helper (Th) cells play critical roles in both host humoral and cellular immunity against parasitic infection and in the immunopathology ...

T follicular helper (Tfh) cells are a subset of CD4 positive t helper cells that are critical for mounting immune responses against pathogens.

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